Publications の更新(2024年)

共著論文

  • Iwamoto, H., Suzuki, H., Masuda, A., Sakaue, T., Nakamura, T., Tanaka, T., Sakai, M., Imamura, Y., Yano, H., Torimura, T., Koga, H., Yasuda, K., Tsurusaki, M., Seki, T., & Kawaguchi, T. (2024). A tumor endothelial cell-specific microRNA replacement therapy for hepatocellular carcinoma. IScience, 27(2), 108797. https://doi.org/10.1016/j.isci.2024.108797
  • Ikegami, H., Shirasawa, K., Yakushiji, H., Toyoda, A., Hayashi, T., Yabe, S., Mori, K., Hirata, C., Nogata, H., & Tashiro, K. (2024). Genome-wide association studies using chromosome-scale genomes of male and female lines redefines two sex-linked loci in linkage disequilibrium in Ficus carica L. Scientia Horticulturae, 336, 113424. https://doi.org/10.1016/j.scienta.2024.113424

Supported Works

  • Ogura, Y., Miyoshi, H., Yoshida, S., Arakawa, F., Takeuchi, M., Nakama, K., Matsuura, M., Takada, H., Yamanaka, Y., Hiraoka, K., & Ohshima, K. (2024). Comprehensive gene expression analysis using RNA sequencing between male and female patients with idiopathic carpal tunnel syndrome. Journal of Orthopaedic Research. https://doi.org/10.1002/jor.25914
  • Asanoma, K., Yagi, H., Onoyama, I., Cui, L., Hori, E., Kawakami, M., Maenohara, S., Hachisuga, K., Tomonobe, H., Kodama, K., Yasunaga, M., Ohgami, T., Okugawa, K., Yahata, H., Kitao, H., & Kato, K. (2024). The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer. The Journal of Biological Chemistry, 300(3), 105695. https://doi.org/10.1016/j.jbc.2024.105695
  • Sakaue, T., Koga, H., Iwamoto, H., Nakamura, T., Masuda, A., Tanaka, T., Suzuki, H., Suga, H., Hirai, S., Hisaka, T., Naito, Y., Ohta, K., Nakamura, K., Selvendiran, K., Okabe, Y., Torimura, T., & Kawaguchi, T. (2024). Pancreatic Juice-Derived microRNA-4516 and microRNA-4674 as Novel Biomarkers for Pancreatic Ductal Adenocarcinoma. Gastro Hep Advances, 3(6), 761–772. https://doi.org/10.1016/j.gastha.2024.04.011
  • Yamaguchi, H., Nishimura, Y., Matsuse, D., Sekiya, H., Masaki, K., Tanaka, T., Saiga, T., Harada, M., Kira, Y., Dickson, D. W., Fujishima, K., Matsuo, E., Tanaka, K. F., Yamasaki, R., Isobe, N., & Kira, J. (2024). A rapidly progressive multiple system atrophy-cerebellar variant model presenting marked glial reactions with inflammation and spreading of α-synuclein oligomers and phosphorylated α-synuclein aggregates. Brain, Behavior, and Immunity, 121, 122–141. https://doi.org/10.1016/j.bbi.2024.07.004

シングルセル解析 (scRNA-seq) の解説

シングルセル解析 (scRNA-seq) についての情報提供を開始しました。

おもに、Seurat を用いた解析方法について紹介予定です。

https://zenn.dev/d01/articles/02f56e1bb5f9f9

また、シングルセル解析に関連するキーワードについてもまとめています。

https://zenn.dev/d01/scraps/599ab06e50b82c

シングルセル解析について、お困りのことがありましたら、どうぞご相談ください。

DNBSEQ によるシーケンス

セルイノベーターでは、自社内の DNBSEQ によるシーケンスサービスも提供しています。
一般的な RNA-seq 向けのシーケンス (6G 150b PE) では、
1サンプルあたり、 70,000 円(税抜)です。

また、多数のサンプルをまとめてご依頼される方向けに、
「レーン買い切りサービス」を提供しています。

1レーン (82.5 G 150b PE) あたり、 600,000 円(税抜)となります。
1レーンにつき最大 16 サンプルのシーケンスが可能です。
(その場合の1サンプルあたりの価格は、37,500 円(税抜))

生物種によってシーケンス量が変わるため、詳細はお問い合わせください。

メールアドレス:contact@cell-innovator.com
リーフレットへのリンク (DNAseqリーフレット)

* RNA 抽出は別途費用が発生します。

*シーケンスのみの価格です。比較解析費用は、別途発生いたします。

Publications の更新(2023年、追加)

  • Aoyagi, R., Maehara, T., Koga, R., Munemura, R., Tomonaga, T., Murakami, Y., Doi, A., Yamamoto, H., Kiyoshima, T., Kawano, S., & Nakamura, S. (2023). Single-cell transcriptomics reveals granzyme K-expressing cytotoxic Tfh cells in tertiary lymphoid structures in IgG4-RD. The Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2023.08.019
  • Suzuki, H., Iwamoto, H., Seki, T., Nakamura, T., Masuda, A., Sakaue, T., Tanaka, T., Imamura, Y., Niizeki, T., Nakano, M., Shimose, S., Shirono, T., Noda, Y., Kamachi, N., Sakai, M., Morita, K., Nakayama, M., Yoshizumi, T., Kuromatsu, R., … Torimura, T. (2023). Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors. Cancer Communications (London, England), 43(4), 415–434. https://doi.org/10.1002/cac2.12411
  • Inada, A., Yasunami, Y., Yoshiki, A., Nabeshima, Y.-I., & Inada, O. (2023). Greb1 Transiently Accelerates Pancreatic β-Cell Proliferation in Diabetic Mice Exposed to Estradiol. The American Journal of Pathology, 193(8), 1081–1100. https://doi.org/10.1016/j.ajpath.2023.04.012
  • Sakata, N., Yoshimatsu, G., Kawakami, R., Aoyagi, C., & Kodama, S. (2023). Optimal temperature for the long-term culture of adult porcine islets for xenotransplantation. Frontiers in Immunology, 14, 1280668. https://doi.org/10.3389/fimmu.2023.1280668
  • Hirayama, A., Tanaka, K., Tsutsumi, H., Nakanishi, T., Yamashita, S., Mizusaki, S., Ishii, Y., Ota, K., Yoneshima, Y., Iwama, E., & Okamoto, I. (2023). Regulation of PD-L1 expression in non-small cell lung cancer by interleukin-1β. Frontiers in Immunology, 14, 1192861. https://doi.org/10.3389/fimmu.2023.1192861

Publications の更新(2023年)

  • Hayashi, Y., Kimura, S., Yano, E., Yoshimoto, S., Saeki, A., Yasukochi, A., Hatakeyama, Y., Moriyama, M., Nakamura, S., Jimi, E., & Kawakubo-Yasukochi, T. (2023). Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research1870(2), 119404. https://doi.org/10.1016/j.bbamcr.2022.119404
  • Otsuji, R., Fujioka, Y., Hata, N., Kuga, D., Sangatsuda, Y., Takigawa, K., Funakoshi, Y., Sako, A., Yamamoto, H., Nakamizo, A., Mizoguchi, M., & Yoshimoto, K. (2023). Liquid biopsy with multiplex ligation-dependent probe amplification targeting cell-free tumor DNA in cerebrospinal fluid from patients with adult diffuse glioma. Neuro-Oncology Advances5(1). https://doi.org/10.1093/noajnl/vdac178

Publications の更新(2022年)

  • Munemura, R., Maehara, T., Murakami, Y., Koga, R., Aoyagi, R., Kaneko, N., Doi, A., Perugino, C. A., Della-Torre, E., Saeki, T., Sato, Y., Yamamoto, H., Kiyoshima, T., Stone, J. H., Pillai, S., & Nakamura, S. (2022). Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgG4-related disease and Kimura disease. Journal of Allergy and Clinical Immunology150(2), 440-455.e17. https://doi.org/10.1016/j.jaci.2022.03.034
  • Yokoyama, K., Mitoma, H., Kawano, S., Yamauchi, Y., Wang, Q., Ayano, M., Kimoto, Y., Ono, N., Arinobu, Y., Akashi, K., Horiuchi, T., & Niiro, H. (2022). CEACAM 1, 3, 5 and 6 -positive classical monocytes correlate with interstitial lung disease in early systemic sclerosis. Frontiers in Immunology13https://doi.org/10.3389/fimmu.2022.1016914
  • Hatano, S., Mine, K., Noguchi, N., Matsumoto, M., Baba, Y., & Yoshikai, Y. (2022). MHC class II inhibits the generation of IL‐17A + Vγ6 γδ T cells in the thymus at perinatal stage. European Journal of Immunology52(8), 1366–1368. https://doi.org/10.1002/eji.202149542
  • Kanemura, H., Hayashi, H., Tomida, S., Tanizaki, J., Suzuki, S., Kawanaka, Y., Tsuya, A., Fukuda, Y., Kaneda, H., Kudo, K., Takahama, T., Imai, R., Haratani, K., Chiba, Y., Otani, T., Ito, A., Sakai, K., Nishio, K., & Nakagawa, K. (2022). The Tumor Immune Microenvironment and Frameshift Neoantigen Load Determine Response to PD-L1 Blockade in Extensive-Stage SCLC. JTO Clinical and Research Reports3(8), 100373. https://doi.org/10.1016/j.jtocrr.2022.100373
  • Miyata, N., Ito, T., Nakashima, M., Fujii, S., & Kuge, O. (2022). Mitochondrial phosphatidylethanolamine synthesis affects mitochondrial energy metabolism and quiescence entry through attenuation of Snf1/AMPK signaling in yeast. The FASEB Journal36(7). https://doi.org/10.1096/fj.202101600RR
  • Shinkawa, T., Ohuchida, K., Mochida, Y., Sakihama, K., Iwamoto, C., Abe, T., Ideno, N., Mizuuchi, Y., Shindo, K., Ikenaga, N., Moriyama, T., Nakata, K., Oda, Y., & Nakamura, M. (2022). Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses. Journal of Experimental & Clinical Cancer Research41(1), 89. https://doi.org/10.1186/s13046-022-02301-9
  • Otsuka, H., Yokomizo, H., Nakamura, S., Izumi, Y., Takahashi, M., Obara, S., Nakao, M., Ikeda, Y., Sato, N., Sakamoto, R., Miyachi, Y., Miyazawa, T., Bamba, T., & Ogawa, Y. (2022). Differential effect of canagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice. Biochemical Journal479(3), 425–444. https://doi.org/10.1042/BCJ20210700

Publications の更新(2021年)

  • Supported works 3件(マイクロアレイ、RNA-seq, ChIP-seq)
    • Asai, M., Koike, Y., Kuwatsuka, Y., Yagi, Y., Kashiyama, K., Tanaka, K., Mishima, H., Yoshiura, K., Utani, A., & Murota, H. (2021). Multifaceted array-based keloidal gene expression profiling reveals specific MDFI upregulation in keloid lesions. Clinical and Experimental Dermatology46(7), 1255–1261. https://doi.org/10.1111/ced.14698
    • Tajiri, R., Shiba, E., Iwamura, R., Kubo, C., Nawata, A., Harada, H., Yoshino, K., & Hisaoka, M. (2021). Potential pathogenetic link between angiomyofibroblastoma and superficial myofibroblastoma in the female lower genital tract based on a novel MTG1-CYP2E1 fusion. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc34(12), 2222–2228. https://doi.org/10.1038/s41379-021-00886-8
    • Kawakubo-Yasukochi, T., Yano, E., Kimura, S., Nishinakagawa, T., Mizokami, A., Hayashi, Y., Hatakeyama, Y., Ohe, K., Yasukochi, A., Nakamura, S., Jimi, E., & Hirata, M. (2021). Hepatic glycogenolysis is determined by maternal high-calorie diet via methylation of Pygl and it is modified by oteocalcin administration in mice. Molecular Metabolism54, 101360. https://doi.org/10.1016/j.molmet.2021.101360